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Filling Machine for the Biomedical, Pharmaceutical and Diagnostics Industry
 

While this discussion does include filling machines used in the pharmaceutical industry there are oftentimes much more rigorous application requirements for pharmaceutical filling than in the nutraceutical, biomedical, and diagnostic specialty chemicals industries. Many pharmaceutical applications require complete, regulatory, validated control over all elements of the packaging process including not only the filling aspect but also container closing and handling. To accomplish this requires something much more than a simple, standalone filling machine; a multifunction machine described as a "monoblock" can perform all required functions.  Otherwise, a more simple peristaltic filling machine can handle most applications in the biomedical, diagnostics, nutraceutical industries with some crossover into the pharmaceutical industry.


(click to enlarge) Monoblock Filling Machine for Pharmaceuticals and High  Purity Diagnostic Products


Automatic monoblock fill cap plug systems are typically small footprint platforms designed to handle small or inherently unstable containers that cannot be practically filled and closed on intermittent straight line filling machine. These platforms are typically used for filling pharmaceutical and biomedical high purity products where the requirements for cleanliness are an extreme.

These filling machine systems are usually found in controlled atmospheres i.e. "clean rooms" where the possibility of particle contamination is practically eliminated. Or some monoblock systems incorporate their own laminar flow, hepa-filtered enclosures to isolate the containers in a controlled atmosphere thereby controlling contamination potential.

Small precise fills of controlled pharmaceuticals, injectables and diagnostic reagents followed by special closures such as stoppers, aluminum crimp seals, plugs and screw caps with precise application torque are accomplished on this platform. It should be noted that there are also some industrial chemical applications filling into larger bulk containers that have the same rigorous cleanliness requirements as pharmaceuticals. An example of this would be high purity solvents used in semiconductor manufacturing. Monoblock machines used in industrial applications are much larger in size.

 


(click to enlarge) Peristaltic Filling Machine for Biomedical and Diagnostic Reagent Products

Biomedical and diagnostic products are produced in small size glass and plastic vials. The peristaltic machine is Ideal for these products because of the accuracy required of these small fill sizes but more importantly, the fact that cross contamination of different products is virtually impossible if adherence to good manufacturing practices is followed. 

Cross contamination is avoided because the only thing that touches the liquid is the peristaltic tubing itself which is composed of surgical grade silicone or other inert specialty polymer materials. This tubing is inexpensive and can be easily cleaned, dedicated to a particular liquid, or simply thrown away after use. It can also be sterilized in an autoclave for reuse.  The size of tubing chosen in this machine depends on the fill size and accuracy required. The smaller the diameter of tubing used, the higher the accuracy but the slower the fill rate.  This explains why this machine is best utilized on small fills where high accuracy is needed.  Large fill sizes greater than 1 liter are typically not filled on this type of machine because the fill cycle time can be lengthy.  But for a typical fill size of 5 to 10 ml, again this is the ideal machine.


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